Psilocybin: Reaction with a Fraction of Rat Brain
Science January 13, 1967 L. P. Gilmour, R. D. O’brien 7 citations
Psilocybin, a hallucinogenic compound, produced a blue color when mixed with a specific subfraction of rat-brain mitochondria that likely contains nerve-ending particles. The color formation intensified with higher pH, did not need oxygen, and involved an insoluble component. Chemically related neuroactive substances like bufotenine and serotonin did not cause this effect, and only tyramine or ethylenediaminetetraacetic acid blocked the reaction.