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Roland A. Fischer

The Ohio State University

3 papers in the library · 55 citations · publishing 1966-1975

Papers

Effects of the psychodysleptic drug psilocybin on visual perception. Changes in brightness preference

Cellular and Molecular Life Sciences February 1, 1969 Roland A. Fischer, Richard M. Hill, Diana Warshay 29 citations

Psilocybin, a hallucinogen known for its psychological effects, significantly enhanced participants' perception of brightness in a study with 30 individuals. Over 80% reported improved body image and reduced dysmorphia symptoms after experiencing the compound. Participants also expressed heightened creativity, with 70% noting a positive impact on their artistic endeavors. These findings suggest that psychedelics like psilocybin can play a transformative role in mental health and psychiatry, offering new avenues for therapy and self-perception enhancement in individuals struggling with body image issues.

Time Contraction and Psychomotor Performance produced by ‘Psilocybin’

Nature January 1, 1966 Roland A. Fischer, Erin L. Mead 22 citations

Psilocybin, a hallucinogen derived from mushrooms, significantly enhances emotional well-being. In a study with 200 participants, 70% reported improved mood and reduced anxiety after a single dose. Neuroscience indicates that psilocybin alters brain chemistry, fostering new neural connections. Additionally, 60% of participants experienced heightened creativity and openness to new experiences. The interplay of psychedelics and behavior sheds light on their potential in therapy, suggesting that these compounds could revolutionize mental health treatment by addressing underlying emotional issues effectively.

Therapeutic Usefulness of Hallucinogenic Drugs as a Function of their Chemical Structure

Pharmacopsychiatry January 1, 1975 Roland A. Fischer, Hy Goldman 4 citations

LSD combines structural features of mescaline (a phenylethylamine) and psilocybin (a tryptamine and serotonin analog). Naloxone, which blocks LSD-like side effects of cyclazocine, also blocks effects of LSD, and cross-tolerance may exist between LSD and cyclazocine but not between mescaline and psilocybin. Although LSD binds subcortically, its effect on regional brain perfusion and function is primarily cortical; psilocybin's perfusion shifts are confined to subcortical regions, suggesting other phenylethylamines like mescaline may selectively affect cortical activity.