The psychedelic renaissance: the next trip for psychiatry?
Irish Journal of Psychological Medicine September 23, 2019 John R. Kelly, Annie Baker, Mona Babiker et al. 22 citations
A growing body of preliminary clinical research indicates that psilocybin, a compound found in hallucinogenic fungi, combined with psychological support can improve mood, reduce anxiety, and enhance quality of life. An open-label study showed marked reductions in depression symptoms among participants with treatment-resistant depression. The underlying neurobiological changes include altered brain connectivity and activity in the amygdala and default mode network, as well as increased synaptogenesis and neural plasticity. A randomized, double-blind trial has recently launched across Europe and North America, including a center in Ireland, to further test psilocybin's efficacy for treatment-resistant depression.