Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys
Behavioural Pharmacology March 1, 2004 William E. Fantegrossi, J H Woods, Gail Winger 99 citations
Hallucinogenic compounds such as DMT, mescaline, and psilocybin can produce weak and transient self-administration in rhesus monkeys previously trained to self-administer MDMA. No compound generated reliable responding, and no subject self-administered DOI at rates above those for saline. In some sessions, 3 out of 4 subjects responded at rates between 0.75 and 3.0 responses per second when DMT, mescaline, or psilocybin were available, earning a majority of infusions and appearing intoxicated. This pattern suggests these hallucinogens may have weak reinforcing effects or mixed reinforcing and aversive properties.