B - 61 Psilocybin as a First-Line Treatment of ADHD in Adult Populations
Archives of Clinical Neuropsychology September 12, 2024 James Perry, Cara C. Young, Julie Williams 1 citation
Microdosing psilocybin may offer an alternative treatment for adult ADHD with fewer side effects than standard stimulant medications, which act on dopamine and noradrenaline receptors and often cause significant adverse effects. This literature review examined research from several journals and found that psilocybin, acting primarily on serotonin receptors, not only produces fewer adverse effects but also provides a different therapeutic pathway when stimulants fail. The review highlights the neurological underpinnings—including 5-HT receptor involvement and neural plasticity—that may explain its potential success. Limitations of stimulant medications are also discussed. The findings suggest psilocybin microdosing could benefit adults seeking symptom management with reduced side effects.