PAM trial protocol: a randomised feasibility study of psychedelic microdosing-assisted meaning-centred psychotherapy in advanced stage cancer patients.
Pilot and feasibility studies February 12, 2024 Alesha Wells, A P Suresh Muthukumaraswamy, Eva Morunga et al. 10 citations
A proposed trial will test whether adding a low, non-hallucinogenic dose of LSD to meaning-centred psychotherapy (MCP) is feasible for advanced cancer patients with anxiety or depression. Forty participants (20 Māori, 20 non-Māori) will receive seven MCP sessions plus either an LSD microdose (4-20 µg) or a placebo, under double-blind conditions. Outcomes include feasibility, acceptability, safety, and psychological measures at baseline, during treatment, and at one- and six-month follow-ups. The study aims to determine whether a full-scale trial is possible and to provide initial evidence on whether microdosing may enhance psychological care in this population.