Biological studies of clavine alkaloids targeting CNS receptors
Frontiers in Psychiatry November 21, 2023 Peter Wipf, Nikhil R. Tasker, Ethan J. Pazur 7 citations
Clavine alkaloids, a subclass of ergot alkaloids found widely in nature, have potent physiological effects but remain understudied compared to well-known psychedelics like LSD and psilocybin. This review summarizes their biological properties, compares their pharmacology to ergolines and related psychedelics, and highlights opportunities for developing new structure–activity relationship profiles. Such advances could expand the currently limited structural variety of psychedelic therapeutics, opening new avenues for medicinal chemistry.