Unexpected Detection of Psilocybin in a 100 mg Tramadol Tablet: A Forensic Case Report
SHILAP Revista de lepidopterología December 1, 2025 Amin Reihani, Fatemeh Shaki
A tablet labeled as tramadol 100 mg was found to contain a high concentration of psilocybin, a hallucinogenic compound from certain mushrooms, along with only 60 mg of tramadol. Analysis by gas chromatography–mass spectrometry confirmed the adulteration. Psilocybin is a prodrug of psilocin, which activates serotonin receptors and can cause visual hallucinations, euphoria, and altered cognition. Combining such an adulterant with an opioid like tramadol, especially without known dosages, may intensify dangerous effects. The case highlights the need for drug monitoring and advanced toxicological analysis to address the public health risk of drug adulteration.