Psilocybin
May 1, 2025 Jessi Humphreys, Lou Lukas, Yvan Beaussant et al.
Psilocybin, a psychoactive compound from over 200 mushroom species, has a long history in Indigenous sacred rituals. It binds to serotonin receptors, activating the serotonergic system to promote neuroplasticity, which helps individuals derive meaning from psychedelic experiences. Evidence suggests benefits for major depressive disorder, anxiety disorders, existential suffering, and substance use disorders. Dosing ranges from low psycholytic to high psychoactive levels. While physiological harm to humans appears low, further research is needed on cardiac and neurological safety in diverse and vulnerable groups. Legal access is expanding through decriminalization, legalization, and right-to-try approaches, varying by region.