Therapeutic Potential of Psychedelic Compounds for Substance Use Disorders
Preprints.org October 17, 2024 Tamara Valdez, Valbhi Patel, Dally Senesombath et al. 1 citation preprint
Psychedelics are being reconsidered as treatments for substance use disorders (SUDs) such as alcohol and opioid use disorders, following early 20th-century anecdotal reports and pilot studies that suggested their potential. Legal restrictions and stigma had halted research, but rising rates of SUDs have renewed interest in these compounds. This review examines emerging evidence for psilocybin, ketamine, LSD, MDMA, ayahuasca, ibogaine, and peyote in treating SUDs, focusing on novel pharmacological targets and holistic approaches to improve adherence and efficacy.