Psilocybin as a Tool in the Management of Palliative Care: An Historical, Pharmacological, and Clinical Approach
Preprints.org April 10, 2025 Andrés David Turizo Smith, Natalia Botero Jsramillo, Diana Milena Berrío Cuartas preprint
Psilocybin, a psychedelic compound found in certain mushrooms, has a long history of use in spiritual ceremonies and neuropsychiatric therapy. Although it was classified as a Schedule I substance in 1970, research into its therapeutic potential has revived since the early 2000s, especially in psychiatry and palliative care. This review explores how psilocybin may improve quality of life for palliative care patients by reducing psychological distress and enhancing emotional well-being. The discussion covers historical context, pharmacokinetics, pharmacodynamics, legal status, and future directions for its use in palliative care.