A single dose of psilocybin reduced preference for larger rewards and increased the time taken to choose them in rats, effects that were not tied to delay length and thus not indicative of altered impulsivity. Forty-eight hours after administration, psilocybin also increased the density of activated parvalbumin inhibitory interneurons surrounded by perineuronal nets in the dorsomedial prefrontal cortex. The findings suggest psilocybin decreases appetitive motivation by activating these specific inhibitory neurons.
A single dose of psilocybin reduced preference for larger delayed rewards and increased the time rats took to choose them, measured 48 hours after administration. These effects were not related to changes in impulsivity, as they did not vary with delay length. Psilocybin also increased the density of activated parvalbumin inhibitory interneurons surrounded by perineuronal nets in the dorsomedial prefrontal cortex. The findings suggest psilocybin decreases reward seeking by activating these specific inhibitory neurons.