Adolescent Psychedelic Use and Psychotic or Manic Symptoms
JAMA Psychiatry March 13, 2024 Otto Simonsson, Miriam A. Mosing, Walter Osika et al. 41 citations
Among 16,255 Swedish adolescents, 541 reported past psychedelic use, and 99% of those also used other drugs. After adjusting for other drug use, psychedelic use was associated with fewer psychotic symptoms. However, the link between psychedelic use and manic symptoms depended on genetic vulnerability: adolescents with higher genetic risk for schizophrenia or bipolar I disorder showed more manic symptoms after psychedelic use. The authors urge caution due to study limitations.