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Joop van Gerven

Centre for Human Drug Research

3 papers in the library · 429 citations · publishing 2008-2012

Papers

Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration

Social Neuroscience June 25, 2009 Glenn Dumont, Fred C.g.j. Sweep, R. van der Steen et al. 238 citations

MDMA (ecstasy) causes a strong increase in blood oxytocin levels and enhances feelings of prosociality in healthy people. The changes in prosocial feelings are more closely tied to changes in oxytocin than to changes in MDMA concentration in the blood. This suggests that oxytocin release may be a key mechanism behind the drug's characteristic social effects.

DOI: 10.1080/17470910802649470 MDMA Ecstasy Prosocial behavior Oxytocin +4

Effect of Subanesthetic Ketamine on Intrinsic Functional Brain Connectivity

Anesthesiology August 13, 2012 Marieke Niesters, Najmeh Khalili‐mahani, Christian H. Martini et al. 141 citations

Low-dose S(+)-ketamine alters the brain's intrinsic large-scale functional connectivity, as measured by resting-state fMRI. In twelve healthy men, ketamine increased connectivity in the cerebellum and visual cortex while decreasing connectivity in auditory and somatosensory networks, including regions involved in pain sensing and affective processing such as the amygdala, insula, and anterior cingulate cortex. Pain-related connectivity changes occurred in areas responsible for descending pain inhibition, including the anterior cingulate cortex, insula, orbitofrontal cortex, and brainstem. These connectivity changes correspond to ketamine's known effects on analgesia, psychedelic experiences, and other side effects.

DOI: 10.1097/aln.0b013e31826a0db3 Full text Ketamine Medicine Anterior cingulate cortex Resting State FMRI +3

Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers

Psychopharmacology February 28, 2008 Glenn Dumont, E. Wezenberg, M. M. G. J. Valkenberg et al. 50 citations

Taking MDMA and ethanol together does not worsen the effects of either drug alone. While the impairment caused by each drug condition was relatively moderate, all drug conditions significantly impaired cognitive function.

DOI: 10.1007/s00213-007-1056-9 Full text MDMA Ecstasy Hallucinogen Psychomotor learning +9