After mephedrone was banned, internet vendors began selling substitute products. One widely promoted second-generation compound is Energy 1 (NRG-1), also called naphyrone (naphthylpyrovalerone, O-2482). This substance comes from a group of compounds originally documented in medicinal chemistry research.
Ecstasy (MDMA) use in Britain has declined since 2001 according to the British Crime Survey, but a new form of MDMA powder or crystal has emerged as a 'premium' product, rebranded in response to user dissatisfaction with poor-quality pills. These changes occurred within a policy context that prioritized the drugs-crime relationship through coercive treatment of problem drug users and a focus on binge drinking, leading to a reduction in information, support, and treatment for ecstasy users since the mid-1990s Safer Dancing harm reduction model.
An open-label study of 14 participants found that mood remained positive during the week after receiving MDMA in a clinical setting, contrary to the 'Blue Monday' crash reported by recreational users. Self-reported sleep quality improved at 3- and 6-month follow-ups compared to baseline. No participants used or desired to use illicit MDMA, and anecdotal reports were favorable. The findings suggest that negative after-effects previously associated with MDMA may stem from confounds such as illicit drug sourcing and recreational settings, rather than the drug itself.