University of North Carolina at Chapel Hill
2 papers in the library · publishing 2024
UNC Libraries June 12, 2024 Diberto J.f, Roth B.l
Psilocybin, a psychedelic compound, may act as a fast-acting antidepressant with lasting effects. A study in Neuron by Shao et al. (2021) demonstrates that psilocybin rapidly promotes the growth of dendritic spines in cortical layer V pyramidal neurons. This finding suggests a possible cellular basis for psilocybin's therapeutic benefits in treating depression.
UNC Libraries June 7, 2024 Kami Kim, T Che, Ouliana Panova et al.
Psychedelics such as LSD, psilocybin, and related compounds are used recreationally and are being investigated as treatments for depression, anxiety, and substance abuse. Their therapeutic and hallucinogenic effects depend on activating the 5-HT2A serotonin receptor, but the molecular details were unclear. Using cryo-electron microscopy and X-ray crystallography, researchers determined the structures of the 5-HT2A receptor bound to a hallucinogen, LSD, and an inverse agonist. These structures reveal how the receptor interacts with Gαq protein and changes shape when activated. The findings may guide development of more selective drugs for neuropsychiatric disorders.