Differences in how NMDA antagonists modulate negative affective biases in male rats may serve as a predictor of clinical efficacy in major depressive disorder.
Transl Psychiatry May 29, 2026 Justyna K. Hinchcliffe, Katie Kamenish, Julia Bartlett et al.
The way NMDA antagonists alter negative affective biases in male rats could predict how well these drugs will work in humans with major depressive disorder.