Rearing behaviour in the mouse behavioural pattern monitor distinguishes the effects of psychedelics from those of lisuride and TBG
Frontiers in Pharmacology February 16, 2023 Yahong Chen, Junhong Liu, Yishan Yao et al. 19 citations
Psychedelics like DOM, mescaline, and psilocin reduce mouse locomotor activity at high doses and alter rearing behavior in an inverted U-shaped pattern. Blocking the 5-HT2A receptor with M100907 reversed changes in activity, rearings, and jumps from low-dose DOM, but not holepoking. The hallucinogenic 5-HT2A agonist 25CN-NBOH produced similar effects that were diminished by M100907, while nonhallucinogenic agonists TBG and lisuride did not increase rearing. Discriminant analysis distinguished all four psychedelics from nonhallucinogenic agonists based on behavior alone, suggesting increased rearing in mice may differentiate hallucinogenic from nonhallucinogenic 5-HT2A agonists.