Daniel Polari

Universidade Federal do Rio Grande do Norte

2 papers in the library · 38 citations · publishing 2017

Papers

Behavioral Changes Over Time Following Ayahuasca Exposure in Zebrafish

Frontiers in Behavioral Neuroscience July 28, 2017 Robson Savoldi, Daniel Polari, Jaquelinne Pinheiro‐da‐silva et al. 38 citations

Ayahuasca, a traditional Amazonian infusion of Banisteriopsis caapi and Psychotria viridis, contains the hallucinogen DMT and monoamine oxidase inhibitors. In adult zebrafish, low concentrations (0.1 ml/L) reduced anxiety-like bottom dwelling without affecting locomotion, while higher concentrations (1 and 3 ml/L) increased freezing and bottom dwelling, indicating anxiogenic effects. Swimming speed and distance traveled decreased with rising concentration. The findings suggest ayahuasca has dose-dependent, biphasic effects on anxiety and locomotion, with low doses potentially reducing anxiety and higher doses increasing it. Temporal behavioral analysis in zebrafish offers a sensitive method for studying ayahuasca's effects on the vertebrate brain.

DOI: 10.3389/fnbeh.2017.00139 Ayahuasca Anxiety Zebrafish Hallucinogen +3

Behavioral changes over time following ayahuasca exposure in zebrafish

LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) July 28, 2017 Robson Savoldi, Daniel Polari, Jaquelinne Pinheiro Da Silva et al.

Ayahuasca, a traditional Amazonian infusion made from Banisteriopsis caapi stem and Psychotria viridis leaves, contains N,N-dimethyltryptamine (DMT) and monoamine oxidase inhibitors. In adult zebrafish exposed to five concentrations (0, 0.1, 0.5, 1, and 3 ml/L, with 14 fish per group), swimming speed and distance traveled decreased with higher concentrations, while freezing and bottom dwelling increased at 1 and 3 ml/L. At 0.1 ml/L, bottom dwelling declined, suggesting reduced anxiety-like behavior. Low doses did not affect locomotion and appeared anxiolytic, whereas higher doses produced anxiogenic effects. Temporal behavioral analysis in zebrafish offers a sensitive method for studying ayahuasca-induced brain changes.

DOI: 10.3389/fnbeh.2017.00139/full Ayahuasca Anxiety Zebrafish Anxiogenic +7