Daily Administration of Psilocin Mucate (L-130) Produces a Favorable Safety Profile and Anxiolytic Effects in Rodents Exposed to Chronic Unpredictable Mild Stress
Journal of Psychoactive Drugs January 2, 2026 Frederick D. Sancilio, Maghsoud Dariani, Purvi Chavda et al.
A stable salt of psilocin, psilocin mucate (L-130), delivers increased bioavailability and more precise control of therapeutic levels compared to oral psilocybin. In this study, daily dosing of L-130 led to significant reductions in cortisol levels and improved performance on anxiety-related behavioral tasks, including the Elevated Plus Maze, Open Field Test, and Novel Object Recognition Task, while weekly dosing did not generally produce significant results. Clinical assessments and blood analyses suggest L-130 is safe with no toxicological effects. Larger studies are needed to determine optimal doses and dosing schedules.