Association of Hallucinogen Persisting Perception Disorder with Trait Neuroticism and Mental Health Symptoms.
Journal of psychoactive drugs January 1, 2025 Morgan Hadley, Alicia Halliday, James M Stone 1 citation
Hallucinogen Persisting Perception Disorder (HPPD) may be more common than previously thought. Among 415 hallucinogen and other drug users who completed an online questionnaire, 39.7% reported symptoms of Type I HPPD and 4.3% reported symptoms of Type II HPPD. Neuroticism scores did not differ between those with and without HPPD. Individuals with Type II HPPD were more likely to report anxiety, obsessional thoughts, paranoia, hypochondria, and panic attacks, and were also more likely to have used 25I-NBOMe, dextromethorphan, nitrous oxide, and benzodiazepines. Nearly half (47.3%) had never tested their drugs, complicating attribution of HPPD severity to specific substances.