Analysis of 7317 online psychedelic experience reports, mostly about psilocybin, shows that the use of mystical language increases with the self-reported intensity of the experience. At the same time, negative sentiment rises and positive sentiment falls as intensity increases. These results suggest that mystical experiences may coexist with challenging elements during a psychedelic session, a possibility that warrants further qualitative investigation. A new mystical language dictionary is provided for future research.
A cross-sectional analysis of 336 clinical trials on MDMA or psilocybin registered on ClinicalTrials.gov found that 17.6% made major changes to primary outcome measures and 28.6% changed eligibility criteria, most after recruitment began. Among completed trials, 72.0% did not post results on the registry, and most that did exceeded the one-year reporting window. Only 3 of 29 trials with both posted results and publications had fully concordant adverse event reporting; most showed qualitative and quantitative discrepancies. These inconsistencies undermine the credibility and safety evaluation of these trials, and the authors advise greater transparency and stricter adherence to reporting standards.