Acute ketamine withdrawal disrupts memory and monoaminergic neurotransmission in adolescent female rats.
Behavioural brain research March 28, 2026 Lucas Villar Pedrosa Da Silva Pantoja, Luiza Fernanda Ramos Soares, Brenda Costa Da Conceição et al.
Adolescent female rats that received intranasal ketamine for three consecutive days, mimicking weekend recreational use, showed impairments in episodic, social, and working memory 24 hours after the last dose. The memory deficits were accompanied by reduced serotonin and norepinephrine levels in the hippocampus and prefrontal cortex. The findings indicate that early ketamine withdrawal following acute exposure disrupts cognition and monoamine signaling in the adolescent female brain.