Characterization of extensive 2-fluorodeschloroketamine metabolism in pooled human liver microsomes, urine and hair from an addicted patient using high-resolution accurate mass spectrometry.
Journal of analytical toxicology July 22, 2023 Delphine Joseph, Camille Lesueur, Fanny Zerizer et al. 8 citations
Twenty-six potential metabolites of the ketamine derivative 2-fluorodeschloroketamine (2F-DCK) were identified, with 15 reported for the first time. Thirteen metabolites were detected in pooled human liver microsomes, 10 were confirmed in both urine and hair from a chronic user, and all were found in at least one of those samples. Nor-2F-DCK is confirmed as a reliable target analyte; OH-dihydro-nor-2F-DCK and dehydro-nor-2F-DCK are suggested as new target analytes in urine and hair, respectively. Deschloroketamine (DCK) was identified as a 2F-DCK metabolite for the first time, with concentrations in hair segments A (0–3 cm), B (3–6 cm), and C (6–9 cm) of 885, 1,500, and 1,850 pg/mg, respectively. Two seized crystals contained 2F-DCK at 67% and 96% with traces of DCK (0.4% and 0.6%) from cross-contamination.