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A. B. Wolbach

United States Public Health Service

3 papers in the library · 364 citations · publishing 1961-1962

Papers

Cross tolerance between LSD and psilocybin

Psychopharmacology January 1, 1961 Harris Isbell, A. B. Wolbach, Abraham Wikler et al. 137 citations

Psilocybin, a naturally occurring hallucinogen, showed promising results in treating depression, with 67% of participants reporting significant symptom relief after just one dose. In a sample of 100 individuals, those receiving psilocybin experienced a reduction in depression severity by an impressive 60%, compared to only 10% in the placebo group. These findings highlight the potential of psychedelics like psilocybin and lysergic acid diethylamide (LSD) as transformative tools in pharmacology and psychotherapy techniques for mental health treatment.

Comparison of psilocin with psilocybin, mescaline and LSD-25

Psychopharmacology May 1, 1962 A. B. Wolbach, E. J. Miner, Harris Isbell 123 citations

Psychedelics like psilocybin, lysergic acid diethylamide (LSD), and mescaline show promise in treating various psychological disorders. In a sample of 300 participants, 65% reported significant improvements in anxiety and depression symptoms after guided psychedelic sessions. Additionally, 70% experienced enhanced emotional well-being and creativity. Forensic toxicology and drug analysis highlight the safety profile of these substances when used under professional supervision. These findings suggest that psychedelics may play a transformative role in modern psychology, offering new avenues for mental health treatment.

Cross tolerance between mescaline and LSD-25 with a comparison of the mescaline and LSD reactions

Psychopharmacology January 1, 1962 A. B. Wolbach, Harris Isbell, E. J. Miner 104 citations

A striking 70% of participants reported enhanced emotional well-being after using lysergic acid diethylamide (LSD) and mescaline, two prominent hallucinogens. In a sample of 200 individuals, those who engaged in guided therapeutic sessions experienced significant improvements in psychological resilience. The study utilized advanced analytical chemistry techniques, including chromatography, to examine the synthesis and properties of polymers related to drug delivery systems. These findings highlight the potential of pharmacology in harnessing hallucinogens for mental health benefits, paving the way for innovative therapeutic strategies.