William D. Loughman - Mindscape Collective

Papers

LSD and Genetic Damage

Science April 30, 1971 Norman I. Dishotsky, William D. Loughman, Robert E. Mogar et al. 145 citations

Pure LSD ingested in moderate doses does not damage chromosomes in vivo, cause detectable genetic damage, or act as a teratogen or carcinogen in humans. In vitro studies showed chromatid breakage only at concentrations and exposure durations unachievable in humans, with no dose-response relation. Among 126 subjects given pure LSD, only 14.29% had elevated chromosome aberrations, versus 48.91% of 184 users of illicit LSD. Chromosome damage correlated with general drug abuse, not LSD alone. LSD is a weak mutagen effective only at extremely high doses. No cause-and-effect relation with neoplasia has been demonstrated, and case reports of leukemia are rare. Pure LSD is not teratogenic in humans, though illicit LSD use was linked to spontaneous abortions.

DOI: 10.1126/science.172.3982.431 In vivo Chromosome aberration Dna damage Toxicology +4

Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage

Science October 27, 1967 William D. Loughman, Thornton W. Sargent, David M. Israelstam 94 citations

Leukocyte cultures from eight people who had recently taken large doses of LSD showed no significant increase in chromosome abnormalities compared to control cultures.

DOI: 10.1126/science.158.3800.508 Lysergic acid diethylamide Serotonin Chromosome Biology +4