Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients
Life Sciences January 1, 1989 Ramesh Arora, Herbert Y. Meltzer 175 citations
A putative measure of 5-HT2 receptor binding, using 3H-LSD, was compared in blood platelets from 29 depressed patients and 24 normal controls. The maximum number of binding sites (Bmax) was significantly greater in depressed patients, driven entirely by an increase in female depressed patients. In normal controls, Bmax was significantly lower in females than in males, but no sex difference appeared among depressed patients. The binding affinity (Kd) did not differ between groups. Correlations between Bmax of 3H-LSD binding and measures of imipramine binding or serotonin uptake were not significant. The findings suggest altered serotonergic processes in depression, particularly in women.