Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148
Archives of General Psychiatry September 1, 1959 Antonio Balestrieri 76 citations
Tolerance to LSD-25 develops rapidly in both humans and animals, while tolerance to mescaline develops more slowly, as observed in rats. Crossed tolerance between LSD-25 and mescaline was previously demonstrated in three human subjects. The present study aims to confirm these findings and investigate whether rapid tolerance to mescaline occurs in humans, whether such tolerance confers resistance to LSD-25, and whether prolonged administration of BOL-148 produces tolerance to itself and to LSD-25.