An Animal Behavior Model for Studying the Actions of LSD and Related Hallucinogens
Science November 12, 1976 Barry L. Jacobs, Michael E. Trulson, Warren C. Stern 72 citations
Cats injected with LSD display distinctive behaviors, such as limb flick and abortive grooming, that are extremely rare in normal cats but become dominant after treatment. The frequency of these behaviors depends on the LSD dose, and the effects last a long time after a single injection. Repeated LSD administration leads to tolerance. These behaviors are not caused by various control drugs but are triggered by other indole nucleus hallucinogens. Because these behavioral effects are specific, reliable, easy to score, and quantifiable, they provide an animal model for studying LSD and related hallucinogens.