Lysergic Acid Diethylamide (LSD) and Lisuride: Differentiation of Their Neuropharmacological Actions
Science April 30, 1982 Francis J. White, James B. Appel 67 citations
Lisuride, a nonhallucinogenic ergot derivative, shares many pharmacological effects with its hallucinogenic counterpart, lysergic acid diethylamide (LSD). Using animals trained to discriminate between the two drugs, researchers found that the LSD cue resembles that of the serotonin agonist quipazine, while the lisuride cue resembles that of the dopamine agonist apomorphine. These findings support the hypothesis that serotonin plays a key role in the hallucinogenic effects of LSD.