Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans
The International Journal of Neuropsychopharmacology June 24, 2015 Patrick C. Dolder, Yasmin Schmid, Manuel Haschke et al. 110 citations
Oral lysergic acid diethylamide (LSD) shows dose-proportional pharmacokinetics, with peak concentrations reached about 1.5 hours after ingestion and a terminal half-life of approximately 3.6 hours. The drug's effects are closely related to its blood concentration, with subjective effects lasting up to 12 hours. These findings provide a reference for clinical studies and for assessing LSD intoxication.