Agonist-Directed Signaling of Serotonin 5-HT2C Receptors Differences Between Serotonin and Lysergic Acid Diethylamide (LSD)
Neuropsychopharmacology August 1, 1999 J Backstrom 55 citations
Lysergic acid diethylamide (LSD) modifies serotonin neurotransmission, and new molecular techniques reveal that its signaling at serotonin 5-HT2C receptors differs from that of the endogenous agonist serotonin. RNA editing of the 5-HT2C receptor dramatically alters LSD's ability to stimulate phosphatidylinositol signaling, offering insight into the mechanisms of partial agonism.