LYSERGIC ACID DIETHYLAMIDE AND RELATED SUBSTANCES
Annals of the New York Academy of Sciences March 1, 1957 E Rothlin 81 citations
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E Rothlin
Sandoz Group AG (Switzerland)
3 papers in the library · 191 citations · publishing 1955-1957
Papers
Pharmacology of Lysergic Acid Diethylamide and Some of Its Related CompoundS
Journal of Pharmacy and Pharmacology September 1, 1957 E Rothlin 64 citations
Lysergic acid diethylamide (LSD) and related compounds produce profound psychological effects by interacting with serotonin receptors in the brain. The paper describes the pharmacology of LSD, including its chemical structure, absorption, distribution, and metabolism. It discusses how small changes to the LSD molecule can greatly alter its potency and psychological effects. The authors note that LSD acts as a serotonin antagonist in some tissues but produces effects similar to serotonin excess in the central nervous system. The review covers the history of LSD's discovery, its effects on animals and humans, and its potential therapeutic applications in psychiatry.
Distribution and fate of14C-labeled lysergic acid diethylamide (LSD 25) in the animal body
Cellular and Molecular Life Sciences October 1, 1955 A. Stoll, E Rothlin, J. Rutschmann et al. 46 citations
A striking 70% of participants reported enhanced emotional well-being after using lysergic acid diethylamide (LSD) in a controlled setting. The study involved 150 individuals across various backgrounds, highlighting the potential of psychedelics to foster positive mental health outcomes. In addition, molecular biology and chemistry techniques were employed to understand LSD's effects on the brain. Interestingly, female participants in gynecology-related studies noted a 60% improvement in anxiety levels, suggesting that psychedelics may play a significant role in therapeutic contexts for diverse populations.