Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brasil; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brasil.
2 papers in the library · 3 citations · publishing 2023
Lysergic Acid Diethylamide (LSD) is metabolized in the model organism Caenorhabditis elegans, producing a range of metabolites identified through ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry. The findings illuminate metabolic pathways and pharmacokinetics of LSD, demonstrating that C. elegans is a suitable system for studying psychedelic compound metabolism and supporting further research into therapeutic applications.
LSD is metabolized into several compounds in the roundworm Caenorhabditis elegans, as shown by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry. The identified metabolites reveal specific metabolic pathways and offer insights into LSD's pharmacokinetics. The work demonstrates that C. elegans is a suitable model for studying psychedelic compound metabolism, providing a foundation for further research on LSD's therapeutic potential.