Systematic Characterization of LSD metabolites in C. elegans by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry
bioRxiv Preprint Server June 19, 2023 Christiane Martins de Vasconcellos Silveira, Vanessa Farelo Dos Santos, Isis Moraes Ornelas et al. preprint
LSD is metabolized into several compounds in the roundworm Caenorhabditis elegans, as shown by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry. The identified metabolites reveal specific metabolic pathways and offer insights into LSD's pharmacokinetics. The work demonstrates that C. elegans is a suitable model for studying psychedelic compound metabolism, providing a foundation for further research on LSD's therapeutic potential.