Validated Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Analyzing LSD, iso-LSD, nor-LSD, and O-H-LSD in Blood and Urine
Journal of Analytical Toxicology June 1, 2009 Arthur C.k. Chung, J. Hudson, G Mckay 19 citations
A validated ultra-performance liquid chromatography-tandem mass spectrometry method can confirm and quantify lysergic acid diethylamide (LSD) and three of its metabolites—iso-LSD, nor-LSD, and O-H-LSD—in blood and urine. Detection limits are as low as 5 pg/mL in blood for LSD and iso-LSD, and 10 pg/mL in urine for all analytes. The method is linear, accurate, and precise across specified concentration ranges. Applied to samples from a suspected LSD user, it marks the first reported detection of O-H-LSD in blood.