LSD Administered as a Single Dose Reduces Alcohol Consumption in C57BL/6J Mice
Frontiers in Pharmacology August 31, 2018 Kenneth Alper, Bin Dong, Relish Shah et al. 37 citations
A single high dose of LSD (50 μg/kg) reduced alcohol consumption by an average of 17.9% in adult male mice over 46 days, with no change in total fluid intake or activity. A lower dose (25 μg/kg) had no effect. The findings suggest classical hallucinogens warrant further animal research for addiction neurobiology and drug discovery.