Chromosome Abnormality in Offspring of LSD User
JAMA February 9, 1970 Lillian Y. F. Hsu 33 citations
A newborn girl with congenital abnormalities consistent with D1-trisomy was found to have trisomy 13 accompanied by a D/D translocation. Her parents had used lysergic acid diethylamide (LSD) before conception but not during the pregnancy. The authors suggest that LSD may have damaged maternal germ cells prior to fertilization, leading to chromosomal rearrangement. Fertilization involving a gamete with an unbalanced chromosome complement may directly cause the chromosomal aberration observed in the offspring.