DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE (LSD) IN VIVO
Journal of Neurochemistry July 1, 1976 L. Holbrook, Ian R. Brown 42 citations
A single injection of lysergic acid diethylamide (LSD) temporarily breaks apart polysomes, the clusters of ribosomes that assemble proteins, in the brains of young rabbits. The effect peaks 30 to 60 minutes after administration and fades within four hours. Both low (10 μg/kg) and high (100 μg/kg) doses cause this disruption. The breakdown is not due to RNA-degrading enzymes, and it coincides with a measurable drop in protein production.