Phantom Limb Pain: Sub‐Hallucinogenic Treatment With Lysergic Acid Diethylamide (LSD‐25)
Headache The Journal of Head and Face Pain July 1, 1977 M Fanciullacci, E. Del Bene, G Franchi et al. 30 citations
Oral treatment with sub-hallucinogenic doses of lysergic acid diethylamide (LSD-25) improved phantom limb pain in five of seven patients, with two showing striking improvement and three moderate reduction in pain and analgesic use; two patients experienced no benefit. Intravenous infusion or bolus injection of LSD-25 at 10 ng/ml at 0.5 ml/min facilitated 5-HT venospasm. The findings suggest LSD-25 facilitates 5-HT activity centrally, consistent with the hypothesis that phantom limb pain has a central origin.