Psychopharmacological Studies of Lysergic Acid Diethylamide (LSD-25) Intoxication
A M A Archives of Neurology & Psychiatry December 1, 1957 Lincoln D. Clark 19 citations
Recent interest in psychotomimetic drugs has prompted a search for agents that block drug-induced hallucinations and psychological disturbances. Reports conflict: azacyclonol (Frenquel) was said to prevent LSD-25 psychoses, but one author could not confirm this. Chlorpromazine, serotonin, and reserpine have been reported to both ameliorate and intensify LSD-25 effects. Amobarbital sodium and chlorpromazine did not prevent intoxication but had suppressive effects at peak intoxication. The confusion stems from failing to distinguish true pharmacological antagonism (blocking) from suppression.