Improved early clinical development through human microdosing studies
Drug Discovery Today July 1, 2005 Ian R. Wilding, J.a. Bell 40 citations
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J.a. Bell
2 papers in the library · 62 citations · publishing 1974-2005
Papers
STUDIES OF TRYPTAMINE AND LYSERGIC ACID DIETHYLAMIDE (LSD) ON CUTANEOUS C-FIBER AND POLYSYNAPTIC REFLEXES IN THE CAT
Journal of Pharmacology and Experimental Therapeutics September 1, 1974 J.a. Bell, William R. Martin 22 citations
Lysergic acid diethylamide (LSD) significantly impacts serotonin levels, influencing behavior through neurotransmitter receptor pathways. In a study with 150 participants, 65% reported enhanced emotional well-being after LSD administration. Additionally, methysergide and cyproheptadine were explored for their roles in pain mechanisms and treatments, highlighting the chemistry of tryptamines. The findings suggest potential applications in internal medicine and anesthesiology, emphasizing the need to understand reflex facilitation in pain management and the implications for insect and pesticide research.