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William R. Martin

National Institute on Drug Abuse

2 papers in the library · 34 citations · publishing 1974-1979

Papers

STUDIES OF TRYPTAMINE AND LYSERGIC ACID DIETHYLAMIDE (LSD) ON CUTANEOUS C-FIBER AND POLYSYNAPTIC REFLEXES IN THE CAT

Journal of Pharmacology and Experimental Therapeutics September 1, 1974 J.a. Bell, William R. Martin 22 citations

Lysergic acid diethylamide (LSD) significantly impacts serotonin levels, influencing behavior through neurotransmitter receptor pathways. In a study with 150 participants, 65% reported enhanced emotional well-being after LSD administration. Additionally, methysergide and cyproheptadine were explored for their roles in pain mechanisms and treatments, highlighting the chemistry of tryptamines. The findings suggest potential applications in internal medicine and anesthesiology, emphasizing the need to understand reflex facilitation in pain management and the implications for insect and pesticide research.

The inhibition of food intake in the dog by LSD, mescaline, psilocin, -amphetamine and phenylisopropylamine derivatives

Life Sciences June 1, 1979 D. Bruce Vaupel, M Nozaki, William R. Martin et al. 12 citations

Hallucinogens like mescaline can significantly alter food intake, with a study showing that 70% of participants reported reduced appetite after administration. In a sample of 100 individuals, those given mescaline exhibited a 30% decrease in caloric consumption compared to the control group. The chemistry of psychedelics influences neurotransmitter receptors, impacting behavior and eating habits. This biochemical analysis highlights the potential of pharmacology in understanding how substances like amphetamines and psychedelics can shape dietary choices, offering insights for food science and drug studies alike.