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Richard H. Rech

2 papers in the library · 46 citations · publishing 1981-1984

Papers

The effects of d-lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), pentobarbital and methaqualone on punished responding in control and 5,7-dihydroxytryptamine-treated rats

Pharmacology Biochemistry and Behavior May 1, 1981 Randall L. Commissaris, William H. Lyness, Richard H. Rech 29 citations

The effects of hallucinogens (LSD and DOM) on punished behavior in rats differ from those of sedatives (pentobarbital and methaqualone), and this difference depends on serotonin (5-HT) neurons. Pentobarbital and methaqualone produced large increases (400-600% of control) in punished responding with little decrease in water intake, while hallucinogens produced only moderate increases (125-175% of control) and similarly depressed unpunished responding. Destroying serotonin neurons with a neurotoxin blocked the hallucinogens' effect on punished responding but did not alter the effects of pentobarbital or methaqualone. The hallucinogens' capacity to decrease water intake was also potentiated by serotonin neuron destruction, indicating that serotonin involvement distinguishes these drug classes.

DOI: 10.1016/0091-3057(81)90121-0 Psilocybin Lysergic acid diethylamide Serotonin Hallucinogen +7

Behavioral effects of intracerebroventricular administration of LSD, DOM, mescaline or lisuride

Pharmacology Biochemistry and Behavior August 1, 1984 David J. Mokler, Richard H. Rech 17 citations

Lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), mescaline, and the non-hallucinogenic LSD analogue lisuride were administered directly into the brain's lateral ventricle (intracerebroventricular, ICV) or injected into the abdomen (intraperitoneal, IP) of rats, and their effects on a fixed-ratio 40 operant behavior were compared. ICV administration of LSD, DOM, and mescaline disrupted behavior more potently than IP administration, with mescaline showing a 30-fold greater potency via ICV (ED50 74 micrograms) than IP (ED50 2251 micrograms). Lisuride showed no difference in potency between routes (ED50 4 micrograms both), suggesting its non-hallucinogenic effects are mediated differently.

DOI: 10.1016/0091-3057(84)90227-2 Mescaline Lysergic acid diethylamide Lisuride Ed50 +6