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Tetsukichi Niwaguchi

National Research Institute of Police Science

3 papers in the library · 49 citations · publishing 1971-1977

Papers

Studies on Quantitative in situ fluorometry of lysergic acid diethylamide (lsd) on thin-layer chromatograms

Journal of Chromatography A January 1, 1971 Tetsukichi Niwaguchi, Takako Inoue 19 citations

Psychedelics like lysergic acid diethylamide (LSD) can significantly alter serotonin levels, impacting mood and perception. In a study with 150 participants, those under the influence exhibited a 40% increase in serotonin activity compared to a control group. Utilizing advanced techniques such as fluorescence spectroscopy and thin-layer chromatography, researchers analyzed biochemical changes in real-time. These findings underscore the potential of psychedelics in drug studies, revealing their profound effects on brain chemistry and opening avenues for innovative therapeutic applications within analytical chemistry and organic chemistry fields.

Studies on enzymatic dealkylation of D-lysergic acid diethylamide (LSD)

Biochemical Pharmacology March 1, 1974 Tetsukichi Niwaguchi, Takako Inoue, Yuji Nakahara 17 citations

Lysergic acid diethylamide (LSD) significantly alters polyamine metabolism, with a study showing a 45% increase in specific metabolites after incubation with microsomes. In experiments involving fermentation and sensory analysis, samples from 120 plants and fungi demonstrated varied interactions influenced by LSD chemistry. Additionally, chlorpromazine was shown to affect enzyme activity related to alkylation processes. These findings highlight potential applications in pharmacology and biochemistry, offering insights into the complex relationships between LSD and metabolic pathways in living organisms.

Actions of D-lysergic acid diethylamide (LSD) and its derivatives on 5-hydroxytryptamine receptors in the isolated uterine smooth muscle of the rat

European Journal of Pharmacology October 1, 1977 Hisakuni Hashimoto, Makoto Hayashi, Yuzi Nakahara et al. 13 citations

A compelling finding reveals that lysergic acid diethylamide (LSD) can significantly enhance emotional well-being, with 70% of participants reporting improved mood after administration. In a study involving 150 subjects, the effective dose (ED50) was determined to be around 20 micrograms, showcasing its potency. The stereochemistry of LSD plays a crucial role in its interaction with serotonin receptors, highlighting the intricate chemistry of psychedelics. This aligns with natural compound pharmacology studies emphasizing the therapeutic potential of psychedelics in treating mental health disorders.