Comparison of tetrahydrocannabinol and synhexyl in man
Clinical Pharmacology & Therapeutics November 1, 1968 Leo E. Hollister, R. K. Richards, H. K. Gillespie 195 citations
A synthetic isomer of tetrahydrocannabinol (THC) was compared to a semisynthetic THC-like compound, synhexyl, in 16 volunteers. THC doses ranged from 341 to 946 µg per kilogram (median 581), while synhexyl doses ranged from 633 to 2,666 µg per kilogram (median 1,370). The clinical syndromes produced by the two drugs were similar, though synhexyl had a slower onset and was only about one third as potent. At higher doses, effects resembled those of psychotomimetics like LSD, but differed in that sedation was prominent, euphoria lasted longer, dreamlike sequences were more pronounced, and there were no sympathomimetic effects.