Pharmacological and behavioral components of tolerance to LSD and mescaline in rats
Pharmacology Biochemistry and Behavior September 1, 1977 Thomas F. Murray, Arthur L. Craigmill, Guenther Fischer 11 citations
Rats trained to press a lever for water on a fixed-ratio schedule (FR-10) developed tolerance to the disruptive effects of LSD and mescaline when the drugs were given daily before testing. Rats that received the same daily doses after each session did not become tolerant when later tested before a session. This suggests that tolerance to the performance-disrupting effects of these hallucinogens depends on the opportunity to practice the behavior while under the drug's influence, indicating a behavioral compensatory mechanism rather than a purely pharmacological one.