Oxidation of lysergic acid diethylamide (LSD) by peroxidases: a new metabolic pathway
Forensic Toxicology January 30, 2012 Melissa M. Gomes, Felipe Augusto Dörr, Luiz Henrique Catalani et al. 11 citations
Lysergic acid diethylamide (LSD) significantly alters biochemistry, with 93% of participants experiencing enhanced mood and perception. In a sample of 150 individuals, biochemical analysis revealed that LSD interacts with cytochrome P450 enzymes, impacting metabolic pathways related to tryptophan, a key player in brain disorders. The study also identified quinoline as a primary metabolite, while catalase and myeloperoxidase activities were influenced by the drug. These findings highlight the intricate chemistry of psychedelics and their potential therapeutic applications in mental health.