The Development and Application of a Gas Chromatography-Mass Spectrometric (GC-MS) Assay to Determine the Presence of 2-Oxo-3-Hydroxy-LSD in Urine
Journal of Analytical Toxicology May 1, 2003 B.t. Burnley, Stephen A. George 14 citations
A gas chromatography-mass spectrometry method was developed to measure the 2-oxo-3-hydroxy metabolite of lysergic acid diethylamide in urine, with a detection limit of 0.5 ng/mL and quantitation limit of 1.0 ng/mL. The assay was linear from 0.5 to 50.0 ng/mL. Applied to 600 urine specimens from suspected LSD abusers in the West Midlands, U.K., only 25 screened positive by immunoassay, and 11 were confirmed by GC-MS. Concentrations in confirmed specimens ranged from 1.7 to 55.8 ng/mL. The method enables future audits of LSD abuse and helps distinguish drug misuse from organic disorders.