Direct Screening of Urine for MDMA and MDA by Liquid Chromatography-Tandem Mass Spectrometry*
Journal of Analytical Toxicology January 1, 2003 Helena K. Nordgren, Olof Beck 43 citations
Liquid chromatography-tandem mass spectrometry (LC-MS-MS) with atmospheric pressure chemical ionization detected MDMA and MDA in urine with a 100 ng/mL cutoff and 10% coefficient of variation. In 1000 clinical patient urine samples, the LC-MS-MS method identified nearly four times as many MDMA-positive samples as the immunochemical method, with no false positives and one false negative. The findings suggest LC-MS-MS is a viable alternative to immunochemical screening for drugs of abuse.